Circadian clocks

نویسنده

  • Michael H. Hastings
چکیده

The biological world is not static: organisms inhabit environments which change predictably over the course of the day and night. There will therefore be selective advantage to any individuals able to anticipate these changes and attune their physiology and behaviour accordingly. Anticipation of daily cycles is conferred by endogenous timers, biological clocks with an intrinsic period of approximately one day (hence circadian). It is now widely accepted that circadian timing is a fundamental property of life, and the ubiquitous expression of circadian rhythms has provided the biologist with many ways of looking at the clock. As a result, circadian timing now stands out as a paradigm for the explanation of how apparently complex patterns of behaviour and physiology might arise from the properties of a relatively small number of gene products, acting in single cells.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ribonucleoprotein Complexes That Control Circadian Clocks

Circadian clocks are internal molecular time-keeping mechanisms that enable organisms to adjust their physiology and behavior to the daily surroundings. Misalignment of circadian clocks leads to both physiological and health impairment. Post-transcriptional regulation and translational regulation of circadian clocks have been extensively investigated. In addition, accumulating evidence has shed...

متن کامل

Circadian clocks, diets and aging

Diets and feeding regimens affect many physiological systems in the organism and may contribute to the development or prevention of various pathologies including cardiovascular diseases or metabolic syndromes. Some of the dietary paradigms, such as calorie restriction, have many well-documented positive metabolic effects as well as the potential to extend longevity in different organisms. Recen...

متن کامل

Posttranslational control of the Neurospora circadian clock.

The eukaryotic circadian clocks are composed of autoregulatory circadian negative feedback loops that include both positive and negative elements. Investigations of the Neurospora circadian clock system have elucidated many of the basic mechanisms that underlie circadian rhythms, including negative feedback and light and temperature entrainment common to all eukaryotic clocks. The conservation ...

متن کامل

Synchronizing the Neurospora crassa circadian clock with the rhythmic environment.

The metronomic predictability of the environment has elicited strong selection pressures for the evolution of endogenous circadian clocks. Circadian clocks drive molecular and behavioural rhythms that approximate the 24 h periodicity of our environment. Found almost ubiquitously among phyla, circadian clocks allow preadaptation to rhythms concomitant with the natural cycles of the Earth. Cycles...

متن کامل

Basic science review on circadian rhythm biology and circadian sleep disorders.

The sleep-wake cycle displays a characteristic 24-hour periodicity, providing an opportunity to dissect the endogenous circadian clock through the study of aberrant behaviour. This article surveys the properties of circadian clocks, with emphasis on mammals. Information was obtained from searches of peer-reviewed literature in the PUBMED database. Features that are highlighted include the known...

متن کامل

Circadian Clocks and Metabolism: The Nutrient-Sensing AKT and TOR Pathways Make the Link

How do organisms sense metabolic and nutrient status to set their biological clocks? The significance of recent work showing that nutrient-sensing pathways influence central circadian clocks in Drosophila is discussed.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Current Biology

دوره 7  شماره 

صفحات  -

تاریخ انتشار 1997